Colonic dysmotility and morphological abnormality frequently detected in Japanese patients with irritable bowel syndrome
نویسندگان
چکیده
BACKGROUND/AIMS Colonoscopy and computed tomography (CT) are used primarily to exclude organic diseases in patients with irritable bowel syndrome (IBS), rather than to assess the pathophysiology of IBS. We aimed to evaluate colonic dysmotility and morphology in Japanese patients with IBS. METHODS One hundred eighty-four patients with IBS and 49 asymptomatic controls who underwent colonoscopy in combination with CT colonography or barium enema were retrospectively reviewed between 2008 and 2012. Water-aided colonoscopy was performed without sedation by a single endoscopist. The duration and pattern of colonic movement and cecal intubation time were recorded. To assess colonic morphology, barium enema or CT colonography were performed immediately after colonoscopy. RESULTS Colonic dysmotility was more frequent in the IBS group (28.8% vs. 2.0% in controls, P<0.001), especially in cases of IBS with diarrhea (IBS-D) (IBS with constipation [IBS-C] 28.8% vs. IBS-D 60.0% vs. mixed IBS [IBS-M] 5.1%, P<0.001). Colonic morphological abnormality was more frequent in the IBS group than in the control group (77.7% vs. 24.5%, P<0.001), especially in IBS-M and IBS-C groups (IBS-C 77.5% vs. IBS-D 48.9% vs. IBS-M 100%, P<0.001). Most patients with IBS with colonic dysmotility had experienced stress related to their symptoms. Cecal intubation time was significantly longer in the IBS group than in the control group (12.1±6.9 minutes vs. 4.6±1.9 minutes, P<0.001). CONCLUSIONS Unsedated colonoscopy, combined with radiographic findings, can detect colonic dysmotility and morphological abnormality. Technical difficulties observed during cecal intubation may partially explain the pathophysiology of IBS.
منابع مشابه
The relationship between mental disorders and irritable bowel syndrome
Background: Irritable bowel syndrome (IBS) is a common abnormality and is associated with symptoms like abdominal pain or defecation discomfort (i.e., constipation or diarrhea). Treatment of this abnormality requires a high cost. Psychiatric complications of this syndrome are numerous accordingly %20 to %60 of affected individuals suffers from them. Anxiety, depression and somatoform disorders ...
متن کاملComparing the mental health of patients with irritable bowel syndrome and healthy subjects in Rasht (Iran), 2014-2015
Background and Objective: Irritable bowel syndrome is one of the most common functional gastrointestinal disorders in which psychological factors play an important role in developing and exacerbating the symptoms. The aim of current study was comparing mental health of patients with irritable bowel syndrome with normal individuals alongside the role of mental health predicting high risk of irri...
متن کاملPrevalence of Celiac Disease in Patients with Irritable Bowel Syndrome in Kerman, Iran
Background & Aims: Celiac disease or gluten-sensitive enteropathy is a relatively uncommon digestive disease. Moreover, irritable bowel syndrome (IBS) is a common functional bowel disorder. Some IBS patients have celiac disease, with similar IBS symptoms in addition to some serious complications. The only possible treatment for this condition is changing the patients diet (gluten free diet). Gi...
متن کاملTHE COMPARISON OF MENTAL PATHOLOGY DIMENSIONS OF PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH NON-DIABETIC PATIENTS IN GASTROENTEROLOGY CLINICS OF TEHRAN
Background & Aims: Irritable bowel syndrome is a common chronic disease that up to 20% of patients are referred to gastroenterologists. The aim of this study was to investigate the psychopathology of people with irritable bowel syndrome and non-infected individuals. Materials & Method: The present study was a comparative-comparative study. The statistical population included all patients that c...
متن کاملSeroprevalence of Campylobacter Jejuni in Patients with Irritable Bowel Syndrome and in Healthy Individuals
Abstract Background and Objective: The patients with Post-Infectious Irritable bowel syndrome (PI-IBS), a subtype of irritable bowel syndrome, suffer from bacterial gastroenteritis. Since campylobacter Jejuni (CJ) is one of the most common agents in this syndrome, we aimed to evaluate the prevalence of Campylobacter Jejuni in patients with Irritable Bowel Disease. Material and Methods: Th...
متن کامل